p53 antibodies, metallothioneins, and oxidative stress markers in chronic ulcerative colitis with dysplasia
نویسندگان
چکیده
منابع مشابه
Neutrophil-Dependent Oxidative Stress in Ulcerative Colitis
Neutrophil accumulation within epithelial crypts and in the intestinal mucosa directly correlates with clinical disease activity and epithelial injury in ulcerative colitis (UC). Current advances have defined the mechanisms by which neutrophils are activated or migrate across mucosal epithelia. A better understanding of this process will likely provide new insights into novel treatment strategi...
متن کاملAnti-cyclic citrullinated peptide antibodies in ulcerative colitis, and its relation with disease activity
Background : Ulcerative colitis an inflammatory bowel disease (IBD) and chronically idiopathic immune related that associates with extraintestinal manifestations such as arthritis. Despite of the highly specificity ofanti-cyclic citrullinated peptide (CCP) antibodies for rheumatoid arthritis, their role in IBD remains unclear . There are only a few studies on the prevalence of anti-CCP antibo...
متن کاملp53 expression in patients with ulcerative colitis - associated with dysplasia and carcinoma: a systematic meta-analysis
BACKGROUND Tumor suppressor gene p53 expression has been reported in patients with ulcerative colitis (UC). However, the correlation between p53 expression and UC remains controversial. The aim of this meta-analysis was to investigate the association between p53 expression and different pathological types of UC. METHODS Publications were searched in the PubMed, Embase, EBSCO, Wangfang, and CN...
متن کاملGlutamine relieves oxidative stress through PI3K/Akt signaling pathway in DSS-induced ulcerative colitis mice
Objective(s): Ulcerative colitis (UC) is a kind of complex immune disease, and a major cause of destruction of intestinal barrier and oxidative stress in this field. In this paper, glutamine (Gln) was believed to offer protection against oxidative stress injury in colitis mice.Materials and Methods: Thirty mice were randomly assigned int...
متن کاملDysplasia in ulcerative colitis: still a challenge.
As duration of inflammatory bowel disease (IBD), in particular ulcerative colitis (UC), is a major risk factor for the development of colorectal cancer (CRC), it is rational to propose a screening colonoscopy when the risk starts to increase, i.e., after 8-10 years from the onset of disease. If low-grade dysplasia is detected, the 9-fold increased risk of developing CRC reported in the most rec...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2011
ISSN: 1007-9327
DOI: 10.3748/wjg.v17.i19.2417